Topamax (Topiramate)

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Generic Name: Topiramate
Brand Names: Topamax 
Dosage: 100mg, 200mg
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Topamax (Topiramate) refers to a group of anticonvulsant drugs that block sodium receptors, stop nervous excitement and remove spasms. The drug is effective for the treatment of epileptic syndrome, migraine, and seizures.

Topamax has antispasmodic, analgesic and anti-inflammatory effect.

Side effects

Topamax can cause the following side effects:

  • digestive system – diarrhea, vomiting, nausea, weight loss, loss of appetite;
  • central nervous system – confusion, headache, dizziness, drowsiness, fatigue, depression, hallucinations, anxiety;
  • psychiatric disorders – speech disorders, anxiety, confusion, disorientation, aggressive reactions, mood disorders, agitation, depressed mood, anger, behavioral disorders;
  • sensory organs – decreased vision, myopia, congestion eye irritation, increased intraocular pressure;
  • allergic reactions – hives, itching, inflammation of the mucous membranes, angioedema, dermatitis;
  • infections and infestations – nasopharyngitis;
  • blood and lymphatic system – anemia, leukopenia, lymphadenopathy, thrombocytopenia, eosinophilia;

Precautions

Topamax is contraindicated for patients with:

  1. hypersensitivity and intolerance to components of the drug;
  2. liver and/ or heart failure;
  3. severe brain disease;
  4. malignant tumor;
  5. pregnancy and lactation.

For patients with kidney failure and osteoporosis the medicine should be prescribed with caution.

How to take

The drug is taken orally, regardless of the meal.

Topamax capsules can be swallowed whole or mixed with a small amount (approximately 1 teaspoon) of soft food.

The initial dose is 25 mg per day. Dosage increasing depends on the patient’s clinical indications.

Capsules are designed for patients who have difficulties with swallowing tablets (for example, children and elderly patients).

Drug interactions

Simultaneous administration of Topamax with other AEDs (phenytoin, carbamazepine, valproic acid, phenobarbital, primidone) has no effect on the value of Css in plasma. It is important to monitor phenytoin concentration, if the patient has toxity.

Phenytoin and carbamazepine reduce the concentration of topiramate in plasma. The dose is adjusted depending on the development of the desired clinical effect.

Missed dose

Take the capsule as soon as you remember. However, dont take the double dose and continue the prescribed dosage.

Overdose

Symptoms of overdose include convulsions, drowsiness, speech disturbances, and vision, diplopia, impaired judgment, impaired coordination, lethargy, stupor, hypotension, abdominal pain, dizziness, agitation and depression.

Overdose can be treated by activated carbon, hemodialysis and symptomatic therapy.

It is necessary to carry out common activities aimed at the maintenance of respiratory function and cardiovascular system.

In case of severe overdose, contact emergency services immediately (USA/UK – 911 / 112 / 999).

Storage

The medicine should be kept in a dry place with temperature no higher than 25 C, away from children.

Has a Generic Topamax been approved?

Yes, the following products are equivalent to Topamax and have been approved by the FDA:

  • Manufacturer: MYLAN
    Approval date: October 14, 2009
    Strength(s): 15MG, 25MG
  • Manufacturer: TEVA
    Approval date: April 17, 2009
    Strength(s): 15MG, 25MG
  • Manufacturer: WATSON LABS
    Approval date: April 15, 2009
    Strength(s): 15MG, 25MG
  • Manufacturer: ZYDUS PHARMS USA INC
    Approval date: October 14, 2009
    Strength(s): 15MG, 25MG
  • Manufacturer: ACCORD HLTHCARE
    Approval date: March 27, 2009
    Strength(s): 25MG, 50MG, 100MG, 200MG
  • Manufacturer: ACTAVIS TOTOWA
    Approval date: February 27, 2013
    Strength(s): 25MG, 50MG, 100MG, 200MG
  • Manufacturer: APOTEX INC
    Approval date: March 27, 2009
    Strength(s): 25MG, 50MG, 100MG, 200MG
  • Manufacturer: AUROBINDO PHARMA
    Approval date: March 27, 2009
    Strength(s): 25MG, 50MG, 100MG, 200MG

You can buy Topamax Generic or Topiramate without any prescription online

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