Plavix (Clopidogrel)

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Generic Name: Clopidogrel
Brand Names: Plavix
Dosage: 75mg
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Plavix (Clopidogrel) is used to treat:

  1. Ischemic stroke – is assigned in the interval from 7 days to 6 months after an ischemic stroke;
  2. peripheral arterial disease;
  3. myocardial infarction – drug should be used in few days (maximum – up to 35 days after myocardial infarction);
  4. atherothrombotic and thromboembolic complications; and
  5. acute coronary syndrome.

Side effects

  • Gastrointestinal tract: abdominal pain, diarrhea, nausea, flatulence, gastritis, constipation, vomiting, peptic ulcer of duodenum and stomach, pancreatitis, increased transaminases, hepatitis, colitis, including ulcerative or lymphocytic;
  • central nervous system: dizziness, headache, paresthesia, confusion, impaired sense of taste, hallucinations;
  • hematopoietic system: decrease in the number of eosinophilic and neutrophilic granulocytes, leukopenia, decrease in the number of platelets, severe thrombocytopenia, anemia and pancytopenia / aplastic anemia;
  • skin: itching, rash, urticaria, erythematous rash, angioneurotic edema, lichen planus;
  • cardiovascular system: decrease in blood pressure, vasculitis.

Precautions

Plavix is contraindicated for patients with:

  • hypersensitivity to clopidogrel or any other excipients of the drug;
  • severe hepatic impairment;
  • acute bleeding;
  • rare hereditary galactose intolerance, lactase deficiency and glucose-galactose malabsorption.

The medicine enters breast milk. Taking the drug during breast feeding is not recommended, as safety of use in this case is not validated.

How to take

The medicine is taken orally with a full glass of water, regardless of the meal.

Acute coronary syndrome without elevation of S-T segment:

  • The recommended starting dose is 300 mg daily, while maintenance dose is 75 mg / day.
  • The maximum effect is registered after 3 months of taking the drug.

Prevention of ischemia after ischemic stroke, myocardial infarction, and peripheral arterial disease:

The recommended dosage is 75 mg / day, while duration of treatment lasts from 35 days up to 6 months.

Drug interactions

Plavix enhances the antiplatelet effect of aspirin, heparin, indirect anticoagulants and increase the risk of gastrointestinal tract bleeding.

Combined use of Clopidogrel and warfarin may also increase the risk of bleeding.

Antacids dont effect Plavix absorption.

Missed dose

Take the capsule as soon as you remember. However, dont take the double dose and continue the prescribed dosage.

Overdose

Symptoms of overdose are short-term and prolonged bleeding.

Treatment of overdose includes appropriate remedial measures.

In case of severe overdose, contact emergency services immediately (USA/UK – 911 / 112 / 999).

Storage

The medicine should be kept in a dry place with temperature no higher than 30C, away from children.

Has a Generic Plavix been approved?

Yes, the following manufacturers have been approved by the FDA:

  • Manufacturer: ACCORD HLTHCARE
    Approval date: March 27, 2013
    Strength(s): EQ 75MG BASE, EQ 300MG BASE
  • Manufacturer: ACTAVIS TOTOWA
    Approval date: May 28, 2013
    Strength(s): EQ 75MG BASE
  • Manufacturer: AMNEAL PHARMS
    Approval date: April 11, 2014
    Strength(s): EQ 75MG BASE
  • Manufacturer: APOTEX INC
    Approval date: May 17, 2012
    Strength(s): EQ 75MG BASE
  • Manufacturer: APOTEX INC
    Approval date: March 4, 2014
    Strength(s): EQ 300MG BASE
  • Manufacturer: AUROBINDO PHARMA LTD
    Approval date: May 17, 2012
    Strength(s): EQ 75MG BASE
  • Manufacturer: GATE PHARMS
    Approval date: May 17, 2012
    Strength(s): EQ 300MG BASE

You can buy Plavix Generic or Clopidogrel online without any prescription

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