Diflucan (Fluconazole)

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Generic Name: Fluconazole
Brand Names: Diflucan 
Dosage: 50mg, 150mg, 200mg
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Fluconazole (Diflucan) is antifungal medicine that has highly specific action by inhibiting the enzyme activity of fungi.

It is used to treat:

  • cryptococcosis;
  • generalized candidiasis including candidemia and disseminated candidiasis;
  • mucosal candidiasis (including pharynx, esophagus and invasive bronchopulmonary infections);
  • recurrence of vaginal candidiasis (acute or recurrent);
  • fungal infections;
  • skin mycoses;
  • deep endemic mycoses.

Side effects

Side effects are usually observed at the beginning of the therapy. Keep in mind that elderly and weakened patients have side effects more frequently.

If you feel any of the following side effects, contact your doctor:

  1. digestive system: loss of appetite, changes in taste, abdominal pain, vomiting, nausea, diarrhea, flatulence, rarely – liver dysfunction;
  2. nervous system: headache, dizziness, excessive fatigue, rarely – seizures;
  3. allergic reactions: skin rash, rarely – exudative erythema, oxic epidermal necrolysis, anaphylactoid reactions;
  4. cardiovascular system: prolongation of the QT interval;
  5. others:renal dysfunction, alopecia, hypercholesterolemia, hypertriglyceridemia, hypokalemia.

Precautions

Fluconazole is contraindicated for patients with:

  • congenital galactose intolerance, lactase deficiency or glucose-galactose malabsorption;
  • hypersensitivity to the drug and its components;
  • lactation period.

Don’t take the drug when drinking alcohol. Alcohol may increase drowsiness and dizziness.

How to take

Take each dose with a full glass of water.

Cryptococcal meningitis and other cryptococcal infections: 400 mg (8 capsules of 50 mg) during the first day of drug administration, and then 200-400 mg/day.

Relapse of cryptococcal meningitis for patients with AIDS: 200 mg/day for a long period of time.

Candidemia, disseminated candidiasis: 400 mg/day.

Drug interactions

Simultaneous administration of Fluconazole and Phenytoin can lead to an increase of Phenytoin concentration in plasma.

Combination with Rifampicin reduces AUC by 25.

Concomitant use of the drug and Hydrochlorothiazide may lead to an increase of Fluconazole concentration in plasma by 40 %.

Missed dose

Take the missed dose as soon as you remember. It’s recommended not take a double dose of the medication.

Overdose

Symptoms of an overdose are hallucinations and paranoid behavior.

Overdose treatment includes gastric lavage and forced diuresis.

In case of severe overdose, contact emergency services immediately (USA/UK – 911 / 112 / 999).

Storage

The medicine should be kept in a dry place with temperature no higher than 25C, away from children.

Has a Generic Fluconazole been approved?

Yes. The following products are equivalent to Fluconazole:

fluconazole for suspension;oral

  • Manufacturer: AUROBINDO PHARM
    Approval date: September 18, 2009
    Strength(s): 50MG/5ML, 200MG/5ML
  • Manufacturer: IVAX SUB TEVA PHARMS
    Approval date: September 12, 2007
    Strength(s): 50MG/5ML, 200MG/5ML
  • Manufacturer: ROXANE
    Approval date: July 29, 2004
    Strength(s): 50MG/5ML, 200MG/5ML

fluconazole tablet;oral

  • Manufacturer: APOTEX
    Approval date: July 29, 2004
    Strength(s): 50MG, 100MG, 150MG, 200MG
  • Manufacturer: AUROBINDO PHARMA
    Approval date: October 7, 2008
    Strength(s): 50MG, 100MG, 150MG, 200MG
  • Manufacturer: DR REDDYS LABS INC
    Approval date: July 29, 2004
    Strength(s): 50MG, 100MG , 150MG, 200MG
  • Manufacturer: GLENMARK GENERICS
    Approval date: January 25, 2006
    Strength(s): 50MG, 100MG, 150MG, 200MG

You can buy Fluconazole Generic or Diflucan online without any prescription

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