Abilify (Aripiprazole)

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Generic Name: Aripiprazole
Brand Names: Abilify
Dosage: 10mg, 15mg, 20mg
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Abilify (Aripiprazole) is a neuroleptic drug, which helps to treat acute attacks of schizophrenia and manic episodes of bipolar disorder.
Medication is also characterized by a certain affinity to sites, governing the reuptake of serotonin. However, it has no affinity to muscarinic receptors.
Side effects

Side effects

  • tachycardia or bradycardia, hypotension (including orthostatic), atrioventricular block, cardiac muscle ischemia, phlebitis, beats, palpitations, increased QT-interval, hemorrhage, heart failure, deep vein thrombosis, atrial fibrillation, cardiac arrest. In rare cases: unconsciousness, brain ischemia, atrial flutter, vasovagal syndrome, thrombophlebitis.
  • change in appetite, difficulty swallowing, dental caries, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, colitis, stomatitis. In rare cases: pancreatitis, vomiting blood, bleeding gums, cheilitis, enlargement of the liver, hepatitis.
  • rheumatoid arthritis, tendonitis, arthritis, tendobursit, myopathy, muscle pain, muscle weakness, pain in bones and joints.
  • violation of psychomotor activity, anxiety, depression, tremors, hypersalivation, mania and suicidal thoughts, abnormal gait, confusion, hostility, insomnia. In rare cases: hallucinations, euphoria, decreased reflexes, obsessive thoughts, dystonia, amnesia, hyperactivity, panic reactions.

Precautions

Aripiprazole doesn’t apply in pediatrics and for patients with diabetes. It is also contraindicated for patients with:

  • coronary artery disease, heart failure, a history of myocardial, conduction disorders.
  • increased risk of hypotension (including dehydration, receiving antihypertensives and hypovolemia) and cerebrovascular disease (such patients are at increased risk of orthostatic hypotension).
  • increased risk of hyperthermia (including during exercise, therapy, anticholinergics, hypovolemia, hyperthermia).
  • high risk of aspiration pneumonia (due to the probability of esophageal dysmotility and aspiration).

How to take

The drug is taken orally with a full glass of water, regardless of the meal.

The initial dose is 10-15 mg / day, while the average dose is 15 mg / day.

Drug interactions

  1. Famotidine has no significant effect on the pharmacokinetic profile of Aripiprazole.
  2. Strong inhibitors CYP2 D6 and CYP3 A4 during investigations decreased clearance of the medicine.
  3. Abilify does not lead to a significant change in the pharmacokinetics of substrates CYP2 D6 and CYP3 A4.

Missed dose

Take the missed dose as soon as you remember. However, dont take the double dose and continue the prescribed dosage.

Overdose

Symptoms of overdose include drowsiness, vomiting, weakness and diarrhea. Abilify overdose should be treated by such supportive means as maintenance of a normal airway, artificial ventilation, and oxygenation.

In case of severe overdose, contact emergency services immediately (USA/UK – 911 / 112 / 999).

Storage

The medicine should be kept in a dry place with temperature no higher than 25C, away from children.

Has a Generic Abilify been approved?

Yes. It’s not different from the brand medication.

The following products are equivalent to Abilify and have been approved by the FDA:

  • Manufacturer: ALEMBIC PHARMS LTD
    Approval date: April 28, 2015
    Strength(s): 2MG, 5MG, 10MG, 15MG, 20MG, 30MG
  • Manufacturer: APOTEX INC
    Approval date: July 24, 2015
    Strength(s): 2MG, 5MG, 10MG, 15MG, 20MG, 30MG
  • Manufacturer: AUROBINDO PHARMA LTD
    Approval date: October 8, 2015
    Strength(s): 2MG, 5MG, 10MG, 15MG, 20MG, 30MG
  • Manufacturer: HETERO LABS LTD V
    Approval date: April 28, 2015
    Strength(s): 2MG, 5MG, 10MG, 15MG, 20MG, 30MG
  • Manufacturer: TEVA PHARMS USA
    Approval date: April 28, 2015
    Strength(s): 2MG, 5MG, 10MG, 15MG, 20MG, 30MG
  • Manufacturer: TORRENT PHARMS LTD
    Approval date: April 28, 2015
    Strength(s): 2MG, 10MG, 5MG, 15MG, 20MG, 30MG

You can buy Abilify Generic or Aripiprazole without any prescription online

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